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La caféine: bonne pour le foie?

18/12/2014 | Etudes Compléments alimentaires et Etudes Perte de poids


The Relationship between Coffee Drinking and Liver Function Tests in Korean Men
Park Kwang Rae           Journal of Caffeine Research. December 2014, 4(4): 131-137.

Background: Coffee is known to have a protective effect on liver enzymes. There are a limited number of Asian studies on this subject. We investigated the relationship between coffee and liver function tests in Korean men on a large scale.

Methods: Study participants were consecutive men who had a regular health checkup in a university hospital in Korea. Information on coffee intake, alcohol drinking, and smoking was collected through self-administered questionnaires.

Results: A total of 3,844 men were enrolled in this study. Coffee drinking was positively associated with smoking and alcohol drinking. Coffee drinking was inversely associated with aspartate aminotransferase (AST) and gamma-glutamyl transferase (GGT) concentrations (r=−1.33, p=0.008 and r=−6.35, p=0.007, respectively). Also, increasing levels of coffee consumption was inversely associated with AST and GGT in a multivariate model (p<0.001 and p<0.001, respectively). The relationship between coffee drinking status and alanine aminotransferase (ALT) did not reach statistical significance. However, heavy coffee consumption (≥3 cups/day) was significantly inversely related to ALT compared with mild coffee consumption (<1 cup/day) and non-coffee drinkers in multivariate analyses (p=0.032). All multivariate models were adjusted for age, body mass index, regular exercise, smoking amount, and alcohol drinking status.

Conclusions: Coffee drinking was inversely associated with AST and GGT in apparently healthy Korean men. The relationship showed a dose–response pattern. It was suggested that ALT was lower in heavy coffee consumers (≥3 cups/day) compared with mild coffee consumers (<1 cup/day) and non-coffee drinkers.

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