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Rôles du sulfure d’hydrogène pour les muscles!

12/03/2015 | Etudes Compléments alimentaires et Etudes Perte de poids et Etudes Anti-âge

 

Role of hydrogen sulfide in skeletal muscle biology and metabolism
Sudhakar Veeranki                         Nitric Oxide Volume 46, 30 April 2015, Pages 66–71

• Tissue and species specific differences in endogenous H2S generators are present.
• H2S role in skeletal muscle biology and disease is not yet known.
• H2S might function in anaerobic ATP generation and mitochondrial protection.
• H2S role in metabolic diseases is controversial and needs further investigation.

Hydrogen sulfide (H2S) is a novel endogenous gaseous signal transducer (gasotransmitter). Its emerging role in multiple facets of inter- and intra-cellular signaling as a metabolic, inflammatory, neuro and vascular modulator has been increasingly realized. Although H2S is known for its effects as an anti-hypertensive, anti-inflammatory and anti-oxidant molecule, the relevance of these effects in skeletal muscle biology during health and during metabolic syndromes is unclear. H2S has been implicated in vascular relaxation and vessel tone enhancement, which might lead to mitigation of vascular complications caused by the metabolic syndromes. Metabolic complications may also lead to mitochondrial remodeling by interfering with fusion and fission, therefore, leading to mitochondrial mitophagy and skeletal muscle myopathy. Mitochondrial protection by H2S enhancing treatments may mitigate deterioration of muscle function during metabolic syndromes. In addition, H2S might upregulate uncoupling proteins and might also cause browning of white fat, resulting in suppression of imbalanced cytokine signaling caused by abnormal fat accumulation. Likewise, as a source for H+ ions, it has the potential to augment anaerobic ATP synthesis. However, there is a need for studies to test these putative H2S benefits in different patho-physiological scenarios before its full-fledged usage as a therapeutic molecule. The present review highlights current knowledge with regard to exogenous and endogenous H2S roles in skeletal muscle biology, metabolism, exercise physiology and related metabolic disorders, such as diabetes and obesity, and also provides future directions.

Le sulfure d’hydrogène (H2S) est traditionnellement reconnu comme gaz toxique possédant une odeur d’œufs pourris. Ce n’est qu’au cours des dernières décennies que le H2S s’est retrouvé parmi la famille des gasotransmetteurs avec l’oxyde nitrique et le monoxyde de carbone, et différents effets physiologiques du H2S ont été rapportés. Parmi les mécanismes moléculaires responsables des effets cellulaires les plus reconnus du H2S se trouvent la régulation de l’homéostasie intracellulaire redox et la modification post-traductionnelle des protéines par S-sulfhydration. D’un côté, le H2S peut promouvoir un effet antioxydant et est cytoprotecteur ; de l’autre, le H2S stimule le stress oxydant et est cytotoxique. Cet article de revue résume nos connaissances des effets antioxydants et prooxydants du H2S dans les cellules de mammifères et décrit les propriétés à deux côtés de ce nouveau gasotransmetteur. La régulation redox dans les effets cellulaires du H2S par l’intermédiaire de S-sulfhydration et le rôle du H2S ...

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