Novel Natural Compounds with Potential to Prevent and Treat Skeletal Muscle Atrophy
A Torrent April 2015 The FASEB Journal vol. 29 no. 1 Supplement 737.4
Objective: Chronic muscle inactivity and mechanical unloading (e.g. bed rest and cast immobilization) result in skeletal wasting and weakness. Muscle weakness is also an early and frequent finding in knee Osteoarthritis (OA) and is a risk factor of OA onset. There is a profound need to develop novel therapeutic strategies because current treatments are ineffective. The aim of this study was to investigate the therapeutic potential of two natural substances to combat muscle atrophy: an extract from rooster comb, IB0004 that contains mainly hyaluronic acid; and BIX003, another extract from porcine cartilage, rich in bioactive substances.
Methods: An assay was performed to evaluate the potential to stimulate proliferation of murine C2C12 muscle cells. In another experiment, we evaluated whether IB0004 or BIX003 could prevent muscle atrophy (i.e. myotube thickness).
Results: IB0004 and BIX003 exerted little effect on cell proliferation in 10% FBS growth serum, but they significantly stimulated proliferation in low-serum media after 48 hours treatment (131% and 48% increase, respectively). In addition, treatments with either extract were able to counteract myotube atrophy when compared with the 0% control, as evident from prevention of the 20% reduction in myotube width.
Conclusion: These data indicate that BIX003 and IB0004 have potential anabolic effects on muscle that could counteract cell atrophy under adverse conditions. Both preparations may have therapeutic potential for preventing atrophy in muscle wasting conditions such as disuse atrophy, sarcopenia, and other disorders. Further studies in animal models should be performed to confirm these results.
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