Créatine et myostatine
Chez des hommes non-entraînés, une cure de 8 semaines de créatine (0,05g par kg après charge) augmente de 50 % l’inhibition de la production de myostatine induite par la musculation. Par contre, la créatine n’a pas d’influence sur le niveau de GASP-1 (un bloqueur naturel de myostatine).
Effects of oral creatine and resistance training on serum myostatin and GASP-1
Molecular and Cellular Endocrinology 317 (2010) 25–30
Myostatin is a catabolic regulator of skeletal muscle mass. The purpose of this study was to determine
the effect of resistance training for 8 weeks in conjunction with creatine supplementation on muscle
strength, lean body mass, and serum levels of myostatin and growth and differentiation factor-associated
serum protein-1 (GASP-1). In a double-blinded design 27 healthy male subjects (23.42±2.2 years) were
assigned to control (CON), resistance training + placebo (RT + PL) and resistance training + creatine supplementation
(RT + CR) groups. The protocol consisted of 3 days per week of training for 8 weeks, each
session including three sets of 8–10 repetitions at 60–70% of 1 RM for whole-body exercise. Blood sampling,
muscular strength testing and body composition analysis (full body DEXA) were performed at 0,
4th and 8th weeks. Myostatin and GASP-1 was measured. Resistance training caused significant decrease
in serum levels of myostatin and increase in that of GASP-1. Creatine supplementation in conjunction
with resistance training lead to greater decreases in serum myostatin, but had not additional
effect on GASP-1. The effects of resistance training on serum levels of myostatin and GASP-1,
may explain the increased muscle mass that is amplified by creatine supplementation.
