Circulating follistatin in relation to energy metabolism
Molecular and Cellular Endocrinology Volume 433, 15 September 2016, Pages 87–93 Jakob Schiøler Hansen
• Circulating follistatin is increased in conditions associated with insulin resistance.
• The glucagon-to-insulin ratio has been identified to regulate circulating follistatin.
• The liver is a major source of the circulating follistatin in humans.
• This implies that circulating follistatin is related to energy metabolism.
• These observations elucidate why plasma follistatin is associated with insulin resistance.
Recently, substantial evidence has emerged that the liver contributes significantly to the circulating levels of follistatin and that circulating follistatin is tightly regulated by the glucagon-to-insulin ratio. Both observations are based on investigations of healthy subjects. These novel findings challenge the present view of circulating follistatin in human physiology, being that circulating follistatin is a result of spill-over from para/autocrine actions in various tissues and cells. Follistatin as a liver-derived protein under the regulation of glucagon-to-insulin ratio suggests a relation to energy metabolism. In this narrative review, we attempt to reconcile the existing findings on circulating follistatin with the novel concept that circulating follistatin is a liver-derived molecule regulated by the glucagon-to-insulin ratio. The picture emerging is that conditions associated with elevated levels of circulating follistatin have a metabolic denominator with decreased insulin sensitivity and/or hyperglucagoneimia.
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- Le foie produit de la follistatine
- Quels sont les effets secondaires court terme des suppléments?