Prohibitin in Adipose and Immune Functions
Trends in Endocrinology & Metabolism Volume 27, Issue 8, August 2016, Pages 531–541 Sudharsana R. Ande
Prohibitin (PHB) was discovered in a quest to find genes with antiproliferative functions. However, the attribute of PHB that is responsible for its antiproliferative function remains elusive. Meanwhile, recent studies have established PHB as a pleiotropic protein with roles in metabolism, immunity, and senescence. PHB has cell compartment-specific functions, acting as a scaffolding protein in mitochondria, an adaptor molecule in membrane signaling, and a transcriptional coregulator in the nucleus. However, it remains unclear whether different functions and locations of PHB are interrelated or independent from each other, or if PHB works in a tissue-specific manner. Here, we discuss new findings on the role of PHB in adipose–immune interaction and an unexpected role in sex differences in adipose and immune functions.
- Prohibitin (PHB) plays a role in sex differences in adipose and immune functions.
- PHB overexpression in adipose tissue results in obesity in both male and female mice but only males develop obesity-related metabolic dysregulation, steatohepatitis, and hepatocellular carcinoma (HCC) in a sex-specific manner.
- Overexpression of a mutant Y114F-PHB promotes obesity, adipose inflammation, and insulin resistance, as well as lymph node tumors in a male sex-specific manner but not steatohepatitis and HCC.
- Male mice overexpressing Y114F-PHB develop adult-onset type 1 diabetes when fed a high-fat diet instead of tumors.
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