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Ca fait quand même un peu beaucoup…

Sildenafil induces browning of subcutaneous white adipose tissue in overweight adults
Metabolism Volume 78, January 2018, Pages 106-117

To investigate that short-term treatment of sildenafil can induce browning of subcutaneous white adipose tissue (sWAT) in human adults.

Design
A randomized, double-blinded, placebo-controlled, parallel group trial.

Methods
Sixteen eligibility overweight male subjects were recruited, comparing 100 mg/day sildenafil versus an identical placebo therapy for 7 days. sWAT samples were collected from subjects before and after 7-day sildenafil or placebo interventions.

Results
The results showed that multilocular UCP1-positive adipocytes existed in sWAT samples from subjects after sildenafil treatment. Compared to before treatment in both group as well as after treatment in placebo, sildenafil significantly decreased adipocyte size, increased the expressions of UCP1 protein and mRNA, mitochondrial density, and leak respiratory capacity in sWAT (p < 0.05). Sildenafil also increased plasma cyclic guanosine-3′,5′-monophosphate (cGMP) and catecholamine concentrations (p < 0.05), and consequently activated the expressions of vasodilator-stimulated phosphoprotein (VASP) and p70 ribosomal S6 kinase 1 (S6 K1) (p < 0.05). Sildenafil did not activate typical brown fat.

Conclusions
The current findings demonstrate that sildenafil can induce browning of sWAT in human, and this action may be through cGMP-dependent protein kinase I and mechanistic/mammalian target of rapamycin (mTOR) signaling pathways. Sldenafil may be a promising treatment for metabolic disease.

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