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Effet de l’exercice physique sur les niveaux de GDF-15

23/01/2018 | Etudes sur les hormones et Etudes Musculation

 

Exercise increases circulating GDF15 in humans
Maximilian Kleinert         Mol Met 2017.12.016


Highlights
•Circulating GDF15 increases during exercise and during recovery from exercise in humans.
•Skeletal muscle tissue appears not to be the source for this exercise-induced increase in GDF15 levels.

Objective
The growth differentiation factor 15 (GDF15) is a stress-sensitive circulating factor that regulates systemic energy balance. Since exercise is a transient physiological stress that has pleiotropic effects on whole-body energy metabolism, we herein explored the effect of exercise on a) circulating GDF15 levels and b) GDF15 release from skeletal muscle in humans.

Methods
Seven healthy males either rested or exercised at 67% of their VO2max for 1 h and blood was sampled from the femoral artery and femoral vein before, during, and after exercise. Plasma GDF15 concentrations were determined in these samples.

Results
Plasma GDF15 levels increased 34% with exercise (p < 0.001) and further increased to 64% above resting values at 120 min (p < 0.001) after the cessation of exercise. There was no difference between the arterial and venous GDF15 concentration before, during, and after exercise. During a resting control trial, GDF15 levels measured in the same subjects were unaltered.

Conclusions
Vigorous submaximal exercise increases circulating GDF15 levels in humans, but skeletal muscle tissue does not appear to be the source.

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