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L’acide phosphatidique aide à prendre du muscle

13/06/2013 | Etudes Compléments alimentaires


D. WILLIAMS Journal of Strength and Conditioning Research VOLUME 27 | SUPPLEMENT 4 | APRIL 2013 | S26

Phosphatidic Acid (PA) is a natural phospholipid compound
derived from lecithin which is commonly found in egg yolk,
grains, fish, soybeans, peanuts and yeast. It has been
suggested that PA is involved in several intracellular processes
associated with muscle hypertrophy. Specifically, PA has been
reported to activate protein synthesis through the mammalian
target of rapamycin (mTOR) signaling pathway and thereby
may enhance the anabolic effects of resistance training. To our
knowledge, no one has examined the effect of PA supplementation
in humans while undergoing a progressive resistance
training program.

Purpose: To examine the effect of PA supplementation
on lean soft tissue mass (LM) and strength after 8
weeks of resistance training.

Methods: Fourteen resistancetrained
men (mean 6 SD; age 22.7 6 3.3 yrs; height: 1.78 6
0.10 m; weight: 89.3 6 16.3 kg) volunteered to participate in
this randomized, double-blind, placebo-controlled, repeated
measures study. The participants were assigned to a PA group
(750 mg/day; Mediator, Chemi Nutra, MN, n = 7) or placebo
group (PL; rice flower; n = 7), delivered in capsule form that
was identical in size, shape and color. Participants were tested
for 1RM strength in the bench press (BP) and squat (SQ)
exercise. LM was measured using dual-energy X-ray absorptiometry.
After base line testing, the participants began supplementing
PA or PL for 8 weeks during a progressive resistance
training program intended for muscular hypertrophy. Data
was analyzed using magnitude-based inferences on mean
changes for BP, SQ and LM. Furthermore, the magnitudes of
the inter-relationships between changes in total training volume
and LM were interpreted using Pearson correlation coefficients,
which had uncertainty (90% confidence limits) of
approximately +0.25.

Results: In the PA group, the relationship
between changes in training volume and LM was large (r =
0.69, +0.27; 90%CL), however, in the PL group the relationship
was small (r = 0.21, +0.44; 90%CL). Changes in strength
and LM in PA and PL groups, and qualitative inferences about
the effects are presented in the table below.

Conclusion: PA supplementation was determined to be likely beneficial at
improving SQ and LM over PL by 26% and 64%, respectively.
The strong relationship between changes in total training volume
and LM in the PA group suggest that greater training
volume most likely lead to the greater changes in LM, however,
no such relationship was found with PL group. For the BP data,
the PA group resulted in a 42% greater increase in strength
over PL, although the effect was considered unclear. Practical

Application: While more research is needed to elucidate
mechanism of action; the current findings suggest that in experienced
resistance trained men supplementing 750 mg PA per
day for 8 weeks may likely benefit greater changes in muscle
mass and strength compared with resistance training only.
Acknowledgments: None.

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