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10 g d’acides aminés réduisent la production de myostatine

17/01/2010 | Etudes Compléments alimentaires

 
Essential Amino Acids Increase MicroRNA-499, -208b, and -23a and Downregulate Myostatin and Myocyte Enhancer Factor 2C mRNA Expression in Human Skeletal Muscle Micah J. Drummond, Erin L. Glynn, Christopher S. Fry, Shaheen Dhanani, Elena Volpi and Blake B. Rasmussen Journal of Nutrition,Vol. 139, No. 12, 2279-2284, December 2009 Essential amino acids (EAA) stimulate muscle protein synthesis in humans. However, little is known about whether microRNAs (miRNA) and genes associated with muscle growth are expressed differently following EAA ingestion. Our purpose in this experiment was to determine whether miRNA and growth-related mRNA expressed in skeletal muscle are up- or downregulated in humans following the ingestion of EAA. We hypothesized that EAA would alter miRNA expression in skeletal muscle as well as select growth-related genes. Muscle biopsies were obtained from the vastus lateralis of 7 young adult participants (3 male, 4 female) before and 3 h after ingesting 10 g of EAA. Muscle samples were analyzed for muscle miRNA (miR-499, -208b, -23a, -1, -133a, and -206) and muscle-growth related genes [MyoD1, myogenin, myostatin, myocyte enhancer factor C (MEF2C), follistatin-like-1 (FSTL1), histone deacytylase 4, and serum response factor mRNA] before and after EAA ingestion using real-time PCR. Following EAA ingestion, miR-499, -208b, -23a, -1, and pri-miR-206 expression increased (P < 0.05). The muscle-growth genes MyoD1 and FSTL1 mRNA expression increased (P < 0.05), and myostatin and MEF2C mRNA were downregulated following EAA ingestion (P < 0.05). We conclude that miRNA and growth-related genes expressed in skeletal muscle are rapidly altered within hours following EAA ingestion. Further work is needed to determine whether these miRNA are post-transcriptional regulators of growth-related genes following an anabolic stimulus.

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6 commentaires

United States
Lionel
18/01/2010

Je comprends pas l’anglais, pou résumé ça donne quoi?

Michael Gundill
Michael Gundill
18/01/2010

je crois que tout est dans le titre

Germany
MacWanted
18/01/2010

La myostatine bloque le developement de la masse donc c’est une bonne chose.

United States
Lionel
18/01/2010

La réduction est-elle assez importante pour créer de façon significative un gain de masse musculaire, si oui 10gr (BCAA) a quel moment et fractionner?

Michael Gundill
Michael Gundill
19/01/2010

tu ne vas pas exploser avec 10 g
c’est un plus ainsi qu’une explication de se qui se passe quand on mange et quand on ne manger pas (la synthèse de la myostatine est libre de s’exprimer)

United States
fredo
19/01/2010

Michael,

tu parles des EAA ou des BCAA’S ??
tu conseillerais de les prendre à quel moment ??

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