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L’excentrique augmente la densité des cellules satellites

22/06/2013 | Etudes Musculation


Satellite cell pool expansion is affected by skeletal muscle characteristics
Filippo Macaluso       Muscle & Nerve Volume 48, Issue 1, pages 109–116, July 2013    
We investigated changes in satellite cell (SC) pool size after an acute bout of strenuous exercise and evaluated the influence of baseline SC count and fiber type.

Methods: Participants completed a downhill running (DHR) intervention (5 × 8 min, 2-min rest; 80% VO2max; −10% gradient). Muscle biopsies were taken 7 days before VO2max and 7–9 days after the DHR intervention. Delayed-onset muscle soreness (DOMS) and creatine kinase activity (CK) were measured on days 1, 2, 7, and 9 post-DHR. SCs were identified by Pax7 and laminin staining. Relative distribution of MHC isoforms was determined by electrophoresis.

Results: DOMS and CK peaked on day 1 post-DHR (P < 0.01).
The SC pool increased (26%) after DHR (P = 0.005). SCs/total myonuclei after recovery correlated with baseline SCs (r = 0.979, P = 0.003) and VO2max (r = 0.956, P = 0.011), whereas change in SC pool (Pax7+ cells/total myonuclei: recovery minus baseline) tended to correlate with percent MHC II (r = 0.848; P = 0.06).

Conclusion: Interindividual physiological characteristics affect SC pool expansion after a single bout of DHR and are influenced by VO2max.

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