Curcuma contre les douleurs articulaires

Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis,
Kuptniratsaikul V, Thamlikitkul V, et al, J Altern Complement Med, 2009; 15(8): 891-7.

In a randomized, controlled study involving 107 patients with primary knee osteoarthritis, results indicate that supplementation with Curcuma domestica (Turmeric) extract may be as efficacious and safe as ibuprofen in reducing pain and improving function. The patients were randomized to 800 mg/day ibuprofen (n=55) or 2 g/day Curcuma domestica extract (n=52), for a period of 6 weeks. Significant improvements in pain on level walking, pain on stairs, and functions of knee assessed by time spent during 100-m walk and going up and down a flight of stairs were observed in both groups with no significant difference. Additionally, there was no significant difference in adverse events between the ibuprofen and turmeric groups. Thus, the authors of this study conclude, “C. domestica extracts seem to be similarly efficacious and safe as ibuprofen for the treatment of knee OA.

Le problème n’est pas son efficacité mais son assimilation :

Biological actions of curcumin on articular chondrocytes
Y. Henrotin, A.L. Clutterbuck   Osteoarthritis and Cartilage Volume 18, Issue 2, Pages 141-149 (February 2010)

Objectives
Curcumin (diferuloylmethane) is the principal biochemical component of the spice turmeric and has been shown to possess potent anti-catabolic, anti-inflammatory and antioxidant, properties. This article aims to provide a summary of the actions of curcumin on articular chondrocytes from the available literature with the use of a text-mining tool. We highlight both the potential benefits and drawbacks of using this chemopreventive agent for treating osteoarthritis (OA). We also explore the recent literature on the molecular mechanisms of curcumin mediated alterations in gene expression mediated via activator protein 1 (AP-1)/nuclear factor-kappa B (NF-κB) signalling in chondrocytes, osteoblasts and synovial fibroblasts.

Methods
A computer-aided search of the PubMed/Medline database aided by a text-mining tool to interrogate the ResNet Mammalian database 6.0.

Results
Recent work has shown that curcumin protects human chondrocytes from the catabolic actions of interleukin-1 beta (IL-1β) including matrix metalloproteinase (MMP)-3 up-regulation, inhibition of collagen type II and down-regulation of β1-integrin expression. Curcumin blocks IL-1β-induced proteoglycan degradation, AP-1/NF-κB signalling, chondrocyte apoptosis and activation of caspase-3.

Conclusions
The available data from published in vitro and in vivo studies suggest that curcumin may be a beneficial complementary treatment for OA in humans and companion animals. Nevertheless, before initiating extensive clinical trials, more basic research is required to improve its solubility, absorption and bioavailability and gain additional information about its safety and efficacy in different species. Once these obstacles have been overcome, curcumin and structurally related biochemicals may become safer and more suitable nutraceutical alternatives to the non-steroidal anti-inflammatory drugs that are currently used for the treatment of OA.

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