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17/03/2014 | Etudes Anti-âge

 

Tirasemtiv amplifies skeletal muscle response to nerve activation in humans
Richard Hansen           Muscle & Nerve 2014 Vol. 49 Issue 4

We tested the hypothesis that tirasemtiv, a selective fast skeletal muscle troponin activator that sensitizes the sarcomere to calcium, could amplify the response of muscle to neuromuscular input in humans.


Methods: Healthy men received tirasemtiv and placebo in a randomized, double-blind, 4-period crossover design. The deep fibular nerve was stimulated transcutaneously to activate the tibialis anterior muscle and produce dorsiflexion of the foot. The force-frequency relationship of tibialis anterior dorsiflexion was assessed following dosing.


Results: Tirasemtiv increased force produced by the tibialis anterior in a dose-, concentration-, and frequency-dependent manner with the largest increases [up to 24.5% (SE 3.1), P < 0.0001] produced at sub-tetanic nerve stimulation frequencies (10 Hz).


Discussion: These data confirm that tirasemtiv amplifies the response of skeletal muscle to nerve input in humans. This outcome provides support for further studies of tirasemtiv as a potential therapy in conditions marked by diminished neuromuscular input.

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