Additional file 1: The Antioxidant Food Table

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Les télomères sont comme des coutures sur les bruns d’ADN qui évitent que ceux-ci s’effilochent (meurt). Plus la couture est grande, plus l’ADN est protégé.
Pourtant, avec de longs télomères, on ne vit pas plus longtemps mais on vit mieux plus longtemps. Le sport, les oméga-3,... augmentent la taille des télomères.

Association Between Telomere Length, Specific Causes of Death, and Years of Healthy Life in Health, Aging, and Body Composition, a Population-Based Cohort Study
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2009 64A(8):860-864
Omer T. Njajou, Wen-Chi Hsueh

Although telomere length (TL) is known to play a critical role in cellular senescence, the relationship of TL to aging and longevity in humans is not well understood. In a large biracial population-based cohort, we tested the hypotheses that elderly persons with shorter TL in peripheral white blood cells have poorer survival, shorter life span, and fewer years of healthy life (YHL). Associations were evaluated using Cox proportional hazard models and linear regression analyses where appropriate. TL (in kilo base pairs) was not associated with overall survival (hazard ratio 1.0; 95% confidence interval 0.9–1.1) or death from any specific underlying cause including infectious diseases, cancer, or cardiac and cerebrovascular diseases. TL, however, was positively associated with more YHL (β = 0.08 ± 0.04, p = .03). Findings suggest that TL may not be a strong biomarker of survival in older individuals, but it may be an informative biomarker of healthy aging.

Plus d’info en français :

http://www.inserm.fr/thematiques/cancer/dossiers/telomeres-et-telomerase

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Pycnogenol® treatment of acute hemorrhoidal episodes
Gianni Belcaro, Maria Rosaria Cesarone
Phytotherapy Research Published Online: 29 Dec 2009

We investigated the efficacy of orally and topically applied Pycnogenol® for the management of acute hemorrhoidal attacks in a controlled, randomized study with 84 subjects. Within less than 48 h of onset of an acute attack, patients were enrolled and signs and symptoms were scored. This evaluation was repeated after seven days’ treatment and again seven days following treatment cessation. The decrease in scores was significantly more pronounced in the Pycnogenol®-treated groups than in the control group given placebo,showing the
efficacy of Pycnogenol® for relieving signs and symptoms of acute external hemorrhoids.
In a group of patients given topical (0.5%) Pycnogenol® in addition to oral Pycnogenol® the improvement in symptoms set in significantly faster and was more pronounced. The most prominent symptom, hemorrhoidal bleeding, was completely absent in all patients treated with Pycnogenol® for seven days and also at the 14 days follow-up. In contrast, bleedings were still observed in the control group during the two weeks follow-up. This study indicates that Pycnogenol®, both in oral and in topical form, is effective for controlling this common, disabling health problem. The application of Pycnogenol® eases the management of acute hemorrhoidal attacks and help avoid bleedings.

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Efficacy and safety of Curcuma domestica extracts in patients with knee osteoarthritis,
Kuptniratsaikul V, Thamlikitkul V, et al, J Altern Complement Med, 2009; 15(8): 891-7.

In a randomized, controlled study involving 107 patients with primary knee osteoarthritis, results indicate that supplementation with Curcuma domestica (Turmeric) extract may be as efficacious and safe as ibuprofen in reducing pain and improving function. The patients were randomized to 800 mg/day ibuprofen (n=55) or 2 g/day Curcuma domestica extract (n=52), for a period of 6 weeks. Significant improvements in pain on level walking, pain on stairs, and functions of knee assessed by time spent during 100-m walk and going up and down a flight of stairs were observed in both groups with no significant difference. Additionally, there was no significant difference in adverse events between the ibuprofen and turmeric groups. Thus, the authors of this study conclude, “C. domestica extracts seem to be similarly efficacious and safe as ibuprofen for the treatment of knee OA.

Le problème n’est pas son efficacité mais son assimilation :

Biological actions of curcumin on articular chondrocytes
Y. Henrotin, A.L. Clutterbuck   Osteoarthritis and Cartilage Volume 18, Issue 2, Pages 141-149 (February 2010)

Objectives
Curcumin (diferuloylmethane) is the principal biochemical component of the spice turmeric and has been shown to possess potent anti-catabolic, anti-inflammatory and antioxidant, properties. This article aims to provide a summary of the actions of curcumin on articular chondrocytes from the available literature with the use of a text-mining tool. We highlight both the potential benefits and drawbacks of using this chemopreventive agent for treating osteoarthritis (OA). We also explore the recent literature on the molecular mechanisms of curcumin mediated alterations in gene expression mediated via activator protein 1 (AP-1)/nuclear factor-kappa B (NF-κB) signalling in chondrocytes, osteoblasts and synovial fibroblasts.

Methods
A computer-aided search of the PubMed/Medline database aided by a text-mining tool to interrogate the ResNet Mammalian database 6.0.

Results
Recent work has shown that curcumin protects human chondrocytes from the catabolic actions of interleukin-1 beta (IL-1β) including matrix metalloproteinase (MMP)-3 up-regulation, inhibition of collagen type II and down-regulation of β1-integrin expression. Curcumin blocks IL-1β-induced proteoglycan degradation, AP-1/NF-κB signalling, chondrocyte apoptosis and activation of caspase-3.

Conclusions
The available data from published in vitro and in vivo studies suggest that curcumin may be a beneficial complementary treatment for OA in humans and companion animals. Nevertheless, before initiating extensive clinical trials, more basic research is required to improve its solubility, absorption and bioavailability and gain additional information about its safety and efficacy in different species. Once these obstacles have been overcome, curcumin and structurally related biochemicals may become safer and more suitable nutraceutical alternatives to the non-steroidal anti-inflammatory drugs that are currently used for the treatment of OA.

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Red ginseng root extract mixed with Torilus fructus and Corni fructus improves facial wrinkles and increases type I procollagen synthesis in human skin: a randomized, double-blind, placebo-controlled study

Cho S, Chung JH, et al, J Med Food, 2009; 12(6): 1252-9.

Summary: In a randomized, double-blind, placebo-controlled study involving 82 healthy female subjects, results indicate that long-term intake of red ginseng extract mixed with Torilus fructus and Corni fructus (herbal mixture) may improve facial wrinkles and increase collagen synthesis in skin. The women were randomized to 3 g/d red ginseng extract-containing herbal mixture or placebo for 24 weeks. At intervention end, significant improvements in facial wrinkles and wrinkle-related biochemical markers (type I procollagen gene and protein expression increased, MMP-9 gene induction was prevented, and fibrillin-1 fiber length was elongated) were observed. Thus, the authors of this study conclude, “A red ginseng extract-containing Torilus fructus and Corni fructus mixture improves facial wrinkles, a clinical sign of photoaging, and this improvement is associated with biochemical and histological evidence of increased collagen synthesis in the dermis. These results substantiate the alleged beneficial effects of red ginseng on photoaging and support its use as an effective “beauty food.”

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Contre les douleurs articulaires.

Dosage quotidien : 3 capsules de 500 mg de glucosamine sulfate avec 200 mg d’oméga-3 (EPA + DHA).

Effect of Glucosamine Sulfate with or without Omega-3 Fatty Acids in Patients with Osteoarthritis

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Plus l’intensité d’effort est grande, plus la réduction de l’envie de fumer est importante.

Effects of exercise on cravings to smoke: The role of exercise intensity and cortisol
Authors: Filippe Scerbo a;  Guy Faulkner b;  Adrian Taylor b; Scott Thomas a
Journal of Sports Sciences, Volume 28, Issue 1 January 2010 , pages 11 - 19

Research consistently demonstrates that a bout of moderate exercise alleviates cravings to smoke among abstaining smokers. The aims of this study were to examine whether doses of exercise (moderate or vigorous) reduced cravings differently, and whether reductions in cravings were associated with changes in cortisol concentration. Using a within-participant, crossover design, 18 participants conducted three 15-min treatment sessions on separate days: passive, walking (45-50% heart rate reserve), and running (80-85% heart rate reserve) conditions. Participants rated cravings at baseline, mid-treatment, and 0, 10, 20, and 30 min after each treatment. Salivary cortisol samples were collected at baseline, immediately after, and 30 min after each condition. Significant group time interactions were identified, demonstrating significant reductions in craving items after the walking and running conditions compared with the passive control. No significant differences in craving reductions were found between walking and running conditions. Post hoc comparisons found that running condition cravings to smoke scores were reduced for a longer duration post-treatment than post-walking condition scores. The decline in cortisol concentration was attenuated in the running group only. Vigorous exercise has a similar effect to moderate exercise in terms of the magnitude of craving reduction. However, performing bouts of moderate-intensity exercise may be a better recommendation for reducing cravings.

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