Etudes sur les hormones : page 20.6

Impacts du gains de poids sur l’aromatisation

23/03/2012 | Etudes sur les hormones et Etudes Perte de poids et Etudes Anti-âge


Weight gain increases human aromatase expression in mammary gland
Dong Chen, Hong Zhao, John S. Coon V, Masanori Ono, Elizabeth K. Pearson, Serdar E. Bulun

Molecular and Cellular Endocrinology Volume 355, Issue 1, 15 May 2012, Pages 114–120

Adulthood weight gain predicts estrogen receptor-positive breast cancer. Because local estrogen excess in the breast likely contributes to cancer development, and aromatase is the key enzyme in estrogen biosynthesis, we investigated the role of local aromatase expression in weight gain-associated breast cancer risk in a humanized aromatase (Aromhum) mouse model containing the coding region and the 5′-regulatory region of the human aromatase gene. Compared with littermates on normal chow, female Aromhum mice on a high fat diet gained more weight, and had a larger mammary gland mass with elevated total human aromatase mRNA levels via promoters I.4 and II associated with increased levels of their regulators TNFα and C/EBPβ. There was no difference in total human aromatase mRNA levels in gonadal white adipose tissue. Our data suggest that diet-induced weight gain preferentially stimulates local aromatase expression in the breast, which may lead to local estrogen excess and breast cancer risk.

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